发布于：2021-07-20
桂朗，女，1984年10月出生，湖北武汉人，博士，副教授，硕士生导师。所属发育生物系。
教育工作背景
2013/01-至今，上海海洋大学，水产与生命学院。
2010/09-2012/09，比利时根特大学（University of Ghent, Belgium），生命科学院，博士后。
2006/09-2010/09，中国科学院海洋研究所，实验海洋生物学重点实验室，硕博联读博士。
2002/09-2006/06，武汉大学，生命科学学院，学士。
教学工作情况
主要承担本科生组织胚胎学，组织发育学，专业英语等课程。
主要研究方向
本人长期从事鱼类生理学与病害防控等方面的研究与应用，以期筛选水产养殖品种优良性状的关键基因并解析作用机理。
主持和参与的科教项目
[1] 2018-12至2022-12国家重点研发计划“重要养殖生物对典型环境胁迫的响应机制和生理生态效应研究”子课题“养殖生物应对温度胁迫的生理和发育响应机制与生态效应研究”（2018YFD0900601）30万，主持。
[2]2014-01至2016-12国家自然科学基金青年基金“铁调素在金钱鱼铁代谢中的作用机理研究”（31302214）23万，主持。
[3]2014年淡水生态与生物技术国家重点实验室开放基金“通过构建金钱鱼肝细胞株进行铁超载差异表达基因的研究 ”（2014FB02）10万，主持。
[4] 2018-12至2022-12国家重点研发计划“重要水产养殖生物抗病和抗逆性状的遗传基础与调控机制”子课题“淡水鱼类抗病与抗逆性状形成的分子机理”（2018YFD0900302），参与。
[5] 2017-01至2020-12国家自然科学基金面上项目“建立青鱂囊胚移植技术开辟鱼类异体生殖的新途径”（ 31672700），参与，排名第二。
[6] 2016-01至2018-12国家自然科学基金青年基金“基于弹涂鱼多型卵黄蛋白原评价环境雌激素活性的研究”（41506193），参与，排名第二。
发表的主要论文情况
[1] Gui, L., Lu, W., Shi, M., Hu, R., & Lu, Y. (2020). Liver DNA methylation and transcriptome between 1- and 3-year-old grass carp. Aquaculture and Fisheries.
[2] Song P#, Sun B, Zhu Y, Zhong Y, Guo J, Gui L*, Li M*(2020). Bucky ball induces primordial germ cell increase in medaka. Gene, in press
[3] Xie J#, Zhong Y#, Zhao Y, Xie W, Guo J, Gui L*, Li M* (2020). Characterization and expression analysis of gonad specific igf3 in the medaka ovary. Aquaculture and Fisheries.
[4] Pu Q#, Ma Y#, Zhong Y, Guo J, Gui L*, Li M*(2020). Characterization and expression analysis of sox3 in medaka gonads. Aquaculture and Fisheries.
[5] Xie Z#, Song P#, Zhong Y, Guo J, Gui L*, Li M*(2020). Medaka gcnf is a component of chromatoid body during spermiogenesis. Aquaculture and Fisheries.
[6] Sun B#, Gui L#, Liu R, Hong Y, Li M*(2020). Medaka oct4 is essential for gastrulation, central nervous system development and angiogenesis. Gene. 733:144270
[7] Sun L#, Zhong Y#, Qiu W, Guo J, Gui L*, Li M*(2020). MiR-26 regulates ddx3x expression in medaka (Oryzias latipes) gonads. Comparative Biochemistry and Physiology Part B. 246-247:110456.
[8] Zhao Y#, Zhang Y#, Zhong Y, Guo J, Gui L*, Li M*(2020). Molecular identification and expression analysis of foxl2 and sox9b in Oryzias celebensis. Aquaculture and Fisheries.
[9] 赵雲, 桂朗*, 陈良标. 罗非鱼产业发展现状[J]. 中国水产, 2020(10).
[10]Zhou T. #, Gui L. #, Liu M., Li W., Hu P., Duarte D.F.C., Niu H., Chen L. (2019) Transcriptomic responses to low temperature stress in the Nile tilapia, Oreochromis niloticus. Fish Shellfish Immunol 84, 1145-56.
[11]Sun B#, Gui L#, Liu R, Hong Y, Li M*. (2019). Medaka oct4 is essential for gastrulation, central nervous system development and angiogenesis. Gene. In press.
[12]Liang X#, W J#, Liu Y#, Peng L, Li Y, Batista F, Power D, Gui L*, Yang J*. (2019). Complete genome of a marine bacterium Vibrio chagasii ECSMB14107 with the ability to infect mussels. Marine Genomics. 10.1016/j.margen.2019.04.008.
[13]Bi Q#, Zhao Y#, Du W#, Lu Y, Gui L, Zheng Z, Yu H, Cui Y, Liu Z, Cui T, Cui D, Liu X, Li Y, Fan S, Hu X, Fu G, Ding J, Ruan C*, Wang L*. Pseudomolecule-level assembly of the Chinese oil tree yellowhorn (Xanthoceras sorbifolium) genome. GigaScience 2019, 8(6). (IF7.3)
[14]桂朗, 张奇亚 (2019) 中国水产动物病毒学研究概述. 水产学报 43, 168-87.
[15]Wang J, Liu Y, Jiang S, Li W, Gui L, Zhou T, Zhai W, Lin Z, Lu J, Chen L. Transcriptomic and epigenomic alterations of Nile tilapia gonads sexually reversed by high temperature. Aquaculture 2019, 508: 167-177.
[16]Zhu,T. #, Gui,L. #, Zhu,Y., Li,Y., Li,M.(2018). Dnd is required for primordial germ cell specification in Oryzias celebensis..Gene,679,36-43.
[17]Gui,L., Li,T., Zhang,Q. (2018). Fish kidney cells show higher tolerance to hyperosmolality than amphibian. Aquaculture and Fisheries, 3, 135-138.
[18]Gui,L., Chinchar,V., Zhang,Q. (2018).Molecular basis of pathogenesis of emerging viruses infecting aquatic animals. Aquaculture and Fisheries, 3, 1-5.
[19]Gui,L., Zhang,Q. (2018) 7.3. Disease prevention and control. Pp577-598. In Gui JF, Tang QS, Li ZJ, Liu JS, Sena SSDe (Eds). Aquaculture in China: Success Stories and Modern Trends. Wiley-Blackwell, Chichester, UK
[20]廉颖,桂朗*,张俊彬.不同渗透压条件下金钱鱼肾原代细胞的差异蛋白分析[J].上海海洋大学学报,2018,27(06):855-863.
[21]Gui,L., Zhang,P., Zhang,Q., & Zhang,J. (2016). Two hepcidins from spotted scat (Scatophagus argus) possess antibacterial and antiviral functions in vitro. Fish & Shellfish Immunology,50,191-199.
[22]Gui,L., Zhang,P., Liang,X., Su,M., Wu,D., & Zhang,J. (2016). Adaptive responses to osmotic stress in kidney-derived cell lines from Scatophagus argus, a euryhaline fish.Gene,583(2),134.
[23]Wang,J. #, Gui,L. #, Chen,Z, & Zhang,Q. (2016). Mutations in the c-terminal region affect subcellular localization of crucian carp herpesvirus (CaHV) GPCR.Virus Genes,52(4),484-494.
[24]Su, M., Mu, X., Gui, L., Zhang, P., Zhou, J., Ma, J., & Zhang, J. (2016). Dopamine regulates renal osmoregulation during hyposaline stress via drd1 in the spotted scat (Scatophagus argus). Sci Rep, 6, 37535.
[25]Su, M., Hu, P., Zhou, J., Ma, J., Li, S., Gui, L., & Zhang, J. (2016). Branchial transcriptional responses of spotted scat, Scatophagus argus, to acute hypo-osmotic stress. Agri Gene, 1, 100-108.
[26]Mu, X., Su, M., Gui, L., Liang, X., Zhang, P., Hu, P., Liu, Z., & Zhang, J. (2015). Comparative renal gene expression in response to abrupt hypoosmotic shock in spotted scat (Scatophagus argus). General & Comparative Endocrinology, 215, 25-35.
[27]Liu, H., Mu, X., Gui, L., Su, M., Li, H., Zhang, G., Liu, Z., & Zhang, J. (2015). Characterization and gonadal expression of foxl2 relative to cyp19a genes in spotted scat Scatophagus argus. Gene, 561(1), 6-14.
[28]Hu, P., Li, S., Zhong, Y., Mu, X., Gui, L., & Zhang, J. (2014). Identification of fxyd genes from the spotted scat (Scatophagus argus): molecular cloning, tissue-specific expression, and response to acute hyposaline stress.Comparative Biochemistry & Physiology Part B Biochemistry & Molecular Biology, 174(1), 15-22.
[29]Gui, L., Wang, B., Li, F. H., Sun, Y. M., Luo, Z., & Xiang, J. (2012). Blocking the large extracellular loop (LEL) domain of fc tetraspanin-3 could inhibit the infection of white spot syndrome virus (WSSV) in Chinese shrimp, Fenneropenaeus Chinensis. Fish & Shellfish Immunology, 32(6), 1008-1015.
[30]桂朗，王兵，王丽燕，李富花，相建海，昆虫围食膜结构与功能概述及其对对虾WSSV病防治研究的启示，海洋科学，第36卷，第4期，126-131页，2012。
[31]Wang, B., Li, F., Luan, W., Xie, Y., Zhang, C., Gui, L., Yan, H., Xiang, J., (2008). Comparison of gene expression profiles of Fenneropenaeus Chinensis challenged with WSSV and Vibrio. Marine Biotechnology. 10(6):664-675.
[32]Zhou,G., Gui, L., Li, Z. Q., Yuan, X, & Zhang, Q. (2008). Generation and characterization of monoclonal antibodies against the flounder Paralichthys olivaceus rhabdovirus. Journal of Virological Methods, 148(1-2):205-210.
[33]Zhou, G, Gui, L., Li, Z, Yuan, X., & Zhang, Q. (2008). Establishment of a Chinese sturgeon (Acipenser sinensis) tail fin cell line and its susceptibility to frog iridovirus. ournal of Fish Biology. 73(8):2058-2067. 2008.
[34]王兵，桂朗，李富花，相建海, 抑制性消减杂交技术结合cDNA MICROARRAY技术在中国明对虾WSSV感染后差异表达基因研究上的应用，海洋与湖沼，第39卷，第5期，455-461页，2008。
[35]桂朗，王兵，李富花，相建海，四跨膜蛋白超家族Tetraspanin的免疫功能研究进展，生物化学与生物物理进展，第35卷，第11期，1231-1238页，2008。
[36]桂朗，李正秋，张奇亚，牙鲆一株弹状病毒病原的分离与鉴定，水生生物学报，第31卷，第3期，345-353页，2007。
[37]Zhang, Q, Tao, J., Gui, L., Zhou, G., Ruan, H., Li, Z. & Gui, J., Isolation and characterization of Scophthalmus maximus rhabdovirus. Diseases of Aquatic Organisms. 74(2):95-105. 2007.
专著和教材情况
参编“十三五” 全国高等院校研究生规划教材《水生生物组织胚胎学》专著， 2019年，科学出版社。
参编全英文著作《Aquaculture in China: Success Stories and Modern Trends》，2018年，Wiley-Blackwell出版社。
联系方式
地址：上海海洋大学水产生命学院B228
E-mail：lgui@shou.edu.cn
