发布于：2020-07-01
邹钧，男，籍贯：湖南，博士，教授，博士生导师。受聘于上海海洋大学水产与生命学院水产动物医学系，为水产动物免疫学与病害防控学科带头人。
现为Fish and Shellfish Immunology副主编，担任Developmental and Comparative Immunology、Aquaculture and Fisheries、Fish and Shellfish Immunology Reports、《水产学报》和《水生生物学报》编委，为国际发育及比较免疫学会亚洲分会理事。
长期从事鱼类免疫学和病害防控研究，首次发现了鱼类白细胞介素1、伽马干扰素、防御素和模式识别受体类RIG-I家族；对鱼类细胞因子的功能与进化进行了系统研究，开创性地提出了脊椎动物干扰素的分子进化理论。在J Immunology、J Virology、PLOS Pathogens、China Science-Life Sciences等期刊发表SCI论文和综述140余篇，参编3部英文编著和一部大学本科教材，论文总引用率达8000余次，H因子为56。
教学工作情况
主讲博士生全英语课程：《Molecular Immunology》
主要研究方向
研究领域：鱼类免疫学、比较免疫学
研究方向：1）鱼类细胞因子与淋巴细胞功能；2）宿主与病原互作机制；3）养殖鱼类疫苗与免疫制剂的作用机理；4）鱼类抗病的分子遗传机制；5）免疫系统起源与分子进化。
主持和参与的科教项目
[1] 国家自然科学基金会，重点项目，草鱼CD4 T辅助（Th）细胞免疫系统及其应答病毒感染的分子机理研究，32030112，2021-01至2025-12，285万元，在研，主持。
[2] 科技部，重点研发计划“蓝色粮仓科技创新”重点专项“重要水产养殖生物抗病和抗逆性状的遗传基础与调控机制”-课题二“淡水鱼类抗病与抗逆性状形成的分子机理”-子课题：虹鳟抗传染性胰坏死病毒感染的分子基础，2018YFD0900302-4，2018-12至2022-12，74万元，在研，主持。
[3] 上海市科学技术委员会，国际科技合作基金项目，鱼类抗菌肽的挖掘与潜在产业应用，19390743100，2019-11至2021-10，30万元，在研，主持。
[4] 国家自然科学基金委员会，国际重大合作项目，31320103913，鱼类伽马干扰素的分泌调控、信号传导及其免疫功能研究，2014-01至2018-12，270万元，已结题，参与。
发表的主要论文情况
H index=56；Total citations>8000
[1] Qin Y, Sun Z, Wang W, Xu J, Wang B, Jia Z, Li X, Wang J, Gao Q, Chen X, Zou J*. Characterization of CD3gamma/delta(+) cells in grass carp (Ctenopharyngodon idella). Dev Comp Immunol. 2021;114:103791.
[2] Li Y, Xiao T*, Zou J*. Fish TNF and TNF receptors. Sci China Life Sci. 2020. doi: 10.1007/s11427-020-1712-4.
[3] Yang Y, Wang J, Xu J, Liu Q, Wang Z, Zhu X, Ai X, Gao Q, Chen X, Zou J*. Characterization of IL-22 Bioactivity and IL-22-Positive Cells in Grass Carp Ctenopharyngodon idella. Front Immunol. 2020;11:586889.
[4] Wang J, Wang W, Xu J, Jia Z, Liu Q, Zhu X, Xia C*, Zou J*. Structural insights into the co-evolution of IL-2 and its private receptor in fish. Dev Comp Immunol. 2020;115:103895.
[5] Wang W, Wang J, Lei L, Xu J, Qin Y, Gao Q, Zou J*. Characterisation of IL-15 and IL-2Rbeta in grass carp: IL-15 upregulates cytokines and transcription factors of type 1 immune response and NK cell activation. Fish Shellfish Immunol. 2020;107:104-117.
[6] Sun Z, Qin Y, Liu D, Wang B, Jia Z, Wang J, Gao Q, Zou J*, Pang Y*. The evolution and functional characterization of CXC chemokines and receptors in lamprey. Dev Comp Immunol. 2020;22:103905.
[7] Liu F, Bols NC, Pham PH, Secombes CJ, Zou J*. Evolution of IFN subgroups in bony fish - 1: Group I-III IFN exist in early ray-finned fish, with group II IFN subgroups present in the Holostean spotted gar, Lepisosteus oculatus. Fish Shellfish Immunol. 2019;95:163-70.
[8] Zhang C, Zhang Q, Wang J, Tian J, Song Y, Xie H, Chang M, Nie P, Gao Q*, Zou J*. Transcriptomic responses of S100 family to bacterial and viral infection in zebrafish. Fish Shellfish Immunol. 2019;94:685-96.
[9] Xue Y, Jiang X, Gao J, Li X, Xu J, Wang J, Gao Q*, Zou J*. Functional characterisation of interleukin 34 in grass carp Ctenopharyngodon idella. Fish Shellfish Immunol. 2019;92:91-100.
[10] Gao J, Jiang X, Wang J, Xue Y, Li X, Sun Z, Xie H, Nie P, Zou J*, Gao Q*. Phylogeny and expression modulation of interleukin 1 receptors in grass carp (Ctenopharyngodon idella). Dev Comp Immunol. 2019;99:103401.
[11] Jiang X, Gao J, Xue Y, Qin Y, Li X, Sun Z, Xie H, Chang M, Nie P, Zou J*, Gao Q*. Identification and expression analysis of IL-4/13 receptors in grass carp. Ctenopharyngodon idella. Fish Shellfish Immunol. 2019;87:254-64.
[12] Wang J, Liu M, Wu Y, Yoon S, Alnabulsi A, Liu F, Fernández-Álvarez C, Wang T, Holland JW, Secombes CJ, Zou J*. Immune-modulation of two BATF3 paralogues in rainbow trout Oncorhynchus mykiss. Mol Immunol. 2018;99:104-14.
[13] Secombes, CJ*, Zou J. Evolution of interferons and interferon receptors. Front in Immunology. 2017;8:209.
[14] Zou J, Secombes CJ*. The Function of Fish Cytokines. Biology (Basel). 2016;5(2).
[15] Zou J*, Redmond AK, Qi Z, Dooley H, Secombes CJ. The CXC chemokine receptors of fish: Insights into CXCR evolution in the vertebrates. Gen Comp Endocrinol. 2015;215:117-31.
[16] Zou J*, Gorgoglione B, Taylor NGH, Summathed T, Lee PT, Panigrahi A, Genet C, Chen YM, Chen TY, Hassan M, Mughal SM, Boudinot P, Secombes CJ. Salmonids have an extraordinary complex type I interferon system: Characterisation of the IFN locus in rainbow trout Oncorhynchus mykiss reveals two novel IFN subgroups. J Immunol. 2014;193:2273-86.
[17] Chang MX#, Zou J#, Nie P, Huang B, Yu Z, Collet B, Secombes CJ*. Intracellular interferons in fish: A unique means to combat viral infection. PLOS Pathogens. 2013;9:e1003736. (# Joint first author).
[18] Chen J, Xu Q, Wang T, Collet B, Corripio-Miyar Y, Bird S, Xie P, Nie P, Secombes CJ, Zou J*. Phylogenetic analysis of vertebrate CXC chemokines reveals novel lineage specific groups in teleost fish. Dev Comp Immunol. 2013;41:137-52.
[19] Zou J*, Secombes CJ. Teleost fish interferons and their role in immunity. Dev Comp Immunol. 2011;35:1376-87.
[20] Chang M, Collet B, Nie P, Lester K, Campbell S, Secombes CJ, Zou J*. Expression and functional characterization of the RIG-I like receptors MDA5 and LGP2 in rainbow trout Oncorhynchus mykiss. J Virol. 2011;85:8403-12.
[21] Qi Z, Nie P*, Secombes C, Zou J*. Intron-containing type I and III interferons (IFN) co-exist in amphibians: refuting the concept that a retroposition event gave rise to type I IFNs. J Immunol. 2010;184:5038-46.
[22] Zou J*, Chang M, Nie P, Secombes CJ. Origin and evolution of the RIG-I like RNA helicase gene family. BMC Evol Biol.2009;9:85.
[23] Chang M, Nie P, Collet B, Secombes CJ, Zou J*. Identification of an additional two-cysteine containing type I interferon in rainbow trout Oncorhynchus mykiss provides evidence of a major gene duplication event within this gene family in teleosts. Immunogenetics. 2009;61:315-25.
[24] Gao Q, Nie P, Thompson KD, Adams A, Wang T, Secombes CJ, Zou J*. The search for the IFN-γ receptor in fish: functional and expression analysis of putative binding and signalling chains in rainbow trout Oncorhynchus mykiss. Dev Comp Immunol. 2009;33:920-31.
[25] Zou J*, Taffala C, Truckle J, Secombes C. Identification of a second group of type I interferons in fish sheds light on interferon evolution in vertebrates. J Immunol. 2007;179:3859-71.
[26] Zou J, Mercier C, Koussounadis A, Secombes CJ. Discovery of multiple beta-defensin like homologues in teleost fish. Mol Immunol. 2007;44:638-47.
[27] Zou J*, Carrington A, Collet B, Dijkstra JM, Bols N, Secombes CJ. Identification and bioactivities of interferon gamma in rainbow trout Oncorhynchus mykiss: the first Th1 type cytokine characterised functionally in fish. J Immunol. 2005;175:2484-94.
[28] Zou J, Yoshiur, Y, Dijkstra JM, Sakai M, Ototake M, Secombes CJ. Identification of an interferon gamma homologue in Fugu, Takifugu rubripes. Fish Shellfish Immunol. 2004;17:403-9.
[29] Zou J, Bird S, Truckle J, Bols N, Horne M, Secombes C. Identification and expression analysis of an IL-18 homologue and its alternatively spliced form in rainbow trout (Oncorhynchus mykiss). Eur J Biochem. 2004;271:1913-23.
[30] Zou J, Secombes CJ, Long L, Miller N, Clem LW,Chinchar VJ. Molecular identification and expression analysis of tumor necrosis factor in channel catfish (Ictalurus punctatus). Dev Comp Immunol. 2003;27:845-58.
[31] Zou J, Clark MS, Secombes CJ. Characterisation, expression and promoter analysis of an interleukin 10 homologue in the puffer fish, Fugu rubripes. Immunogenetics. 2003;55:325-35.
[32] Zou J, Peddie S, Scapigliati G, Zhang Y, Bols NC, Ellis AE, Secombes CJ. Functional characterisation of the recombinant tumor necrosis factors in rainbow trout, Oncorhynchus mykiss. Dev Comp Immunol. 2003;27:813-22.
[33] Zou J, Wang T, Hirono I, Aoki T, Inagawa H, Honda T, Soma GI, Ototake M, Nakanishi T, Ellis AE, Secombes CJ. Differential expression of two tumor necrosis factor genes in rainbow trout, Oncorhynchus mykiss. Dev Comp Immunol. 2002;26:161-72.
[34] Zou J, Holland J, Pleguezuelos O, Cunningham C, Secombes CJ. Factors influencing the expression of interleukin-1 beta in cultured rainbow trout (Oncorhynchus mykiss) leucocytes. Dev Comp Immunol. 2000;24:575-82.
[35] Zou J, Bird S, Minter R, Horton J, Cunningham C, Secombes CJ. Molecular cloning of the gene for interleukin-1beta from Xenopus laevis and analysis of expression in vivo and in vitro. Immunogenetics. 2000;51:332-8.
[36] Zou J, Grabowski PS, Cunningham C, Secombes CJ. Molecular cloning of interleukin 1beta from rainbow trout Oncorhynchus mykiss reveals no evidence of an ice cut site. Cytokine.1999;11:552-60.
[37] Zou J, Neumann NF, Holland JW, Belosevic M, Cunningham C, Secombes CJ, Rowley AF. Fish macrophages express a cyclo-oxygenase-2 homologue after activation. Biochem J. 1999;340:153-9.
[38] Zou J, Cunningham C, Secombes CJ. The rainbow trout Oncorhynchus mykiss interleukin-1 beta gene has a differ organization to mammals and undergoes incomplete splicing. Eur J Biochem. 1999;259:901-8.
[39] Zou J, Trudeau VL, Cui Z, Brechin J, Machenzie K, Zhu Z, Houlihan DF, Peter RE. Estradiol stimulates growth hormone production in female goldfish. Gen Comp Endocrinol. 1997;106:102-12.
专著和教材情况
[1] 主编Fish and Shellfish Immunology特刊《Virus Defences》，Elsevier，2020年7月。
[2] 参编《水产动物免疫学》，中国农业出版社，2020年5月第一版。
[3] 参编《The evolution of the Immune System: Conservation and Diversification》，Academic Press，2016年5月第一版。
[4] 参编《Immunobiology of the Shark》，CRC Press，2015年5月第一版。
[5] 参编《Fish Defenses》，Science Publishers，2009年6月第一版。
联系方式
地址：上海市临港新城沪城环路999号，上海海洋大学水产与生命学院D楼107室
E-mail：jzou@shou.edu.cn
